Within the scope of this project, Biorébus seeks to develop molecules that are able to slow down or reverse the aging process. We consider aging as the degradation of the extracellular environment, i.e. of the extracellular matrix. The energy consumption of the cells linked to oxidative stresses (triggered by ionizing radiation, pollutants, etc.) leads to the accumulation of waste in this matrix. Our approach considers that this accumulated waste will locally modify the architecture of the extracellular matrix and slow down the passage of nutrients to the cells.
Using an approach similar to that implemented in our project against cancer, we have selected molecules that have already been approved and are well known in other medical applications. We are currently conducting in vitro experiments on the molecules that can eliminate the waste accumulated in the extracellular matrix.